If you are making a print of a particular size: 10"X8", or A3, or whatever, you will need to resize and resample your image to make the best use of the printer's capabilities and avoid softening, or other issues. With some software (e.g. Photoshop and Photoshop Elements) you need to have done that before going to the colour management steps in printing. If you are lucky enough to be using Lightroom the software will handle resizing and resampling as part of the colour print output process.